4  Examples

Open science projects are transparent, accessible, and collaborative (see Chapter 1). Below lists examples of Parkinson’s disease research projects that practice open science principles.

4.1 European Parkinson’s Genome-wide Assocition Study (GWAS) Meta-analysis

Authors: The Global Parkinson’s Genetics Program (GP2), Hampton L. Leonard

Brief summary: largest investigation of Parkinson’s disease genetic risk to date

4.2 Accelerating Medicines Partnership–Parkinson’s Disease (AMP-PD)

Authors: Accelerating Medicines Partnership (AMP) Program

Brief summary: public-private partnership between the National Institutes of Health (NIH), multiple biopharmaceutical and life sciences companies, and non-profit organizations. Clinical, whole genome, and transcriptomics data available from harmonized datasets.

4.3 Fox Insight

Authors: The Michael J. Fox Foundation

Brief summary: online clinical study including both cross-sectional and longitudinal surveys. Genetic data (genotyping) and microbiome data (stool & saliva) available from a subsample of participants.

  • Fox DEN - data exploration network for the Fox Insight study that provides investigators with a tool to explore, download, and apply statistical models on aggregated data collected for the Fox Insight online clinical study. Also contains recent publications, documentation, and study resources.

4.4 Parkinson’s Progression Markers Initiative (PPMI)

Authors: The Michael J. Fox Foundation

Brief summary: A large-scale, longitudinal study to identify biomarkers of Parkinson’s disease. Qualified researchers may obtain access to clinical, imaging, ’omics, genetic, sensor, and biomarker data.

4.5 The Parkinson’s Disease Biomarkers Program (PDBP)

Authors: National Institute of Neurological Disorders and Stroke (NINDS)

Brief summary: A project led by NIH/NINDS to discover and validate Parkinson’s biomarkers. Provides access to standardized biomarker data and biospecimens.

4.6 OpenNeuro

Authors: Stanford Center for Reproducible Neuroscience

Brief summary: A free and open platform for validating and sharing BIDS-compliant MRI, PET, MEG, EEG, and iEEG data.

Note

Do you have an example of a Parkinson’s disease research project that practices open science? Submit an issue here and we’ll be sure to add it to this chapter!